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Low Dose Ketamin

Made Wiryana , I Ketut Sinardja, I Gede Budiarta, Tjokorda Gde Agung Senapathi, Made Widnyana, I Wayan Aryabiantara, I Gusti Agung Gede Utara Hartawan, Pontisomaya Parami, Ni Putu Novita Pradnyani, Adinda Putra Pradhana

Made Wiryana
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia. Email: anesthesiology@unud.ac.id

I Ketut Sinardja
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

I Gede Budiarta
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Tjokorda Gde Agung Senapathi
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Made Widnyana
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

I Wayan Aryabiantara
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

I Gusti Agung Gede Utara Hartawan
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Pontisomaya Parami
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Ni Putu Novita Pradnyani
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia

Adinda Putra Pradhana
Department of Anesthesiology, Pain Management and Intensive Care, Udayana University, Sanglah General Hospital, Denpasar-Bali, Indonesia
Online First: February 20, 2017 | Cite this Article
Wiryana, M., Sinardja, I., Budiarta, I., Agung Senapathi, T., Widnyana, M., Aryabiantara, I., Utara Hartawan, I., Parami, P., Novita Pradnyani, N., Putra Pradhana, A. 2017. Low Dose Ketamin. Bali Journal of Anesthesiology 1(1): 13-19. DOI:10.15562/bjoa.v1i1.4


Ketamine binds non-competitive against a phencyclidine receptors bound N-methyl-D-aspartate (NMDA), a receptor that is involved in the pathophysiology of acute pain. Ketamine has been used as an intravenous anesthesia, analgesia for acute and chronic pain at a dose of subanaesthetic. Ketamine is a dissociative anesthetic produces a state with a characteristic strong analgesia, amnesia, and catalepsy. Dissociative components resulting from the effect on the limbic system and talamoneokortikal. Low-dose ketamine as known as analgesia dose ketamine or subanestesia dose is 0.2 to 0.75 mg / kg IV. At low doses, ketamine does not increase the effect psikomimetik like dissociation or deep sedation. The combination with midazolam provides satisfactory sedation, amnesia and analgesia without significant cardiovascular depression.

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